In 2010, Valderrama guest-starred on Disney Channel's series Wizards of Waverly Place playing the role of Theresa Russo's brother, Ernesto.In 2011, he appeared in three episodes of USA Network's Royal Pains as Eric Kassabian, an art dealer.
He made his professional debut in a Spanish-language Pacific Bell commercial.
In animation work, Valderrama voiced Rodrigo in Clifford's Really Big Movie, playing alongside John Ritter, Wayne Brady and Jenna Elfman.
He also voices the main character, Manny, in Disney Channel's Handy Manny series for preschoolers (He even starred in a minisode featuring his acting counterpart).
is an American actor, singer, producer and television personality, best known for the role of Fez in the sitcom That '70s Show (1998–2006) and Carlos Madrigal in American horror television series From Dusk Till Dawn: The Series (2014–).
He was also host of the MTV series Yo Momma (2006–2007), voiced the character of Manny in the children's show Handy Manny (2006–2012) and had recurring roles on Grey's Anatomy, The Ranch and NCIS in 2016.
Valderrama has further performed in several prominent feature films, including Party Monster (2003), Beauty Shop (2005), Fast Food Nation (2006), Unaccompanied Minors (2006), Zoom (2006), Larry Crowne (2011), and The Adderall Diaries (2015).